What’s Filler?

What is a Filler?

The actual word derives its meaning from the word “to fill.”
It is a syringe normally used to provide dimensions in the face area (cheeks, chin, nose ) or remove wrinkles (eye and mouth, nasolabial fold, forehead) based on its composition it can be categorized into Hyaluronic Fillers (HA Fillers) and Non-hyaluronic Filler (Collagen/Calcium Filler).

Advantages and disadvantages of HA Fillers

HA fillers can be dissolved through hyaluronidase; 
it provides security and therefore favored by doctors and have a high market share  of 80-90%. However, absorption is fast resulting in a short life and companies are struggling to develop long-lasting HA fillers. Long lasting Non-HA Fillers do exist, however due to safety issues it is not favored by doctors resulting in a low market share of 10-20%.

Technology behind our Filler

Hyaluronic acid is a polysaccharides polymer consisting of amino and uronic sugar; it does not have the characteristic of a specie nor organ but is a substance largely available in living bodies such as in the eyeball, comb, skin tissue, placenta and shark cartilage. Hyaluronic acid shows excellent biocompatibility and high viscoelasticity when implanted or injected; moreover it is used in diverse ways because of its humectant, antibiosis, anti-inflammatory and lubricating effect.

Leader in HA filler manufacturing

BioPlus’s HA Filler uses Hyaluronic acid that possesses the physical natures mentioned above, to create a product that shows an increased Cross Linking rate by applying the company’s patented High Technology – resulting in a Filler used widely in petit plastic surgery and skin care that won’t harm the human body when injected and that will not dissolve to provide a long-lasting shape. Our product has overcome the conventional Cross-linking technology by applying the patented Multi-staged Cross-linking technology to create three layered small beads that resolves the difficulty of creating a long-lasting HA Filler. Our product is world’s first semi-permanent HA Filler that has increased the entry barriers by applying core technology so that the HA filler does not transform its component after product completion to keep the human body unharmed.


Patented Multi-staged Cross-linking Technology

Patented Multi staged Cross-linking (MCL) technology

High viscosity is obtained through patented stage micro beads manufacturing technology based on cross linked hyaluronic acid

Our products show exceptional volume enhancement due to its outstanding hydrophilic capacity through its stable particle structure.

Our product shows exceptional volume enhancement due to its outstanding hydrophilic capacity through its stable particle structure. Moreover even with a small amount the product allows for easy molding and with a greater volume enhancement effect. Our product successfully achieved a high viscous semi-solid Hyaluronic acid gel through the patented Multi-staged Cross-linking Technology overcoming the technological limitations of conventional filler products. It allows for easy molding due to its high viscosity and small particle size.

After Centrifugation for 30 minutes at 3,000rpm (condition: 50cc of pure water into 1 cc of each test sample)

Hydrohilic capacity

High viscosity

Our product is highly viscous ranging up to 11,000,000 cp.
Strong viscosity allows for a long-lasting filler being migration resistant and contributing to the long-lasting effect.

Safe & Removable

Our Dermal Fillers uses Hyaluronic Acid as base material. According to the Refractive index comparison, the final product shows the exact wavelength pattern as its raw material, proving that our providuct is 100% HA with no chemical alterations during its manufacturing (cross-linking) process.
Moreover our fillers are highly hydrophillic that can be easily dissolved through Hyaluronidase. Although the product itself is long-lasting to natural hyaluronidase, however as the graph below shows fast dissolution of the filler by injection of hyaluronidase.

Results show fast and perfect dissolution through Hyaluronidase.


HyalDew All

HyalDew All is the hardest from among its product line. It’s smaller particle size allows easy molding that can be used in any part of face to enhance volume and improve contour lines on the forehead, glabella, temple, nose, cheeks, fold, Lips, chin, and improve deep wrinkles such as in the nasolabial folds

HyalDew Mid

Hyaldew MID is more comfortable at All and harder than Fine. Because of its small particle size, it can be used on major parts of the face, improving forehead, cheeks, wrinkles and lips.

HyalDew Fine

HyalDew Fine is a less hard and a smaller particle size than HyalDew All. It is effective in the improvement of fine lines.

HyalDew Shine

The elaborate HA manufacturing technology HyalDew Shine applies micro-beads with increase longevity. The high hydrophilic capacity allows effective supply of HA in the skin tissue contributing to a long-lasting anti-aging, elasticity and humectant effect of the skin. HyalDew Shine is a fine product that has eliminated discomforts felt after treatment.


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